Cisco ISE uses probes to collect endpoint attributes that are used in profiling. Probes are software modules that run on the ISE Policy Service Nodes (PSNs) and gather information about the endpoints connected to the network. Probes can use various protocols and methods to collect endpoint attributes, such as RADIUS, DHCP, SNMP, HTTP, DNS, NetFlow, NMAP, Active Directory, and Cisco pxGrid. The collected attributes are then matched to predefined or custom conditions that define the endpoint profiles. Endpoint profiling enables ISE to identify and classify the endpoints and apply the appropriate policies based on their identity, role, and context12. References: 1: Cisco ISE 2.4 Endpoint Profiling - Cisco 2: How To Create an Endpoint Profile - Cisco Community Reference:
https://content.cisco.com/chapter.sjs?uri=/searchable/chapter/content/en/us/td/docs/security/ise/2-6/admin_guide

ETHOS is the Cisco file grouping engine. It allows us to group families of files together so if we see variants of a malware, we mark the ETHOS hash as malicious and whole families of malware are instantly detected.
ETHOS is the Cisco file grouping engine. It allows us to group families of files together so if we see variants of a malware, we mark the ETHOS hash as malicious and whole families of malware are instantly detected.
Reference:
ETHOS = Fuzzy Fingerprinting using static/passive heuristics
ETHOS is the Cisco file grouping engine. It allows us to group families of files together so if we see variants of a malware, we mark the ETHOS hash as malicious and whole families of malware are instantly detected.
ETHOS = Fuzzy Fingerprinting using static/passive heuristics

Cisco AnyConnect with Umbrella Roaming Security module protects a user from a phishing attack by enforcing security at the DNS layer and blocking malicious domains that are used for phishing campaigns. The Umbrella Roaming Security module integrates with the Cisco AnyConnect client and provides always-on security even when no VPN is active. The Umbrella Roaming Security module can replace the existing Cisco Umbrella roaming client or be part of a new AnyConnect deployment12.
Cisco Identity Services Engine (ISE) is not an endpoint solution, but a network access control and policy enforcement platform that can integrate with AnyConnect for posture assessment and compliance3. Cisco AnyConnect with ISE Posture module is used to check the compliance status of the endpoint device and apply the appropriate network access policy based on the posture result4. Cisco AnyConnect with Network Access Manager module is used to manage the network connections and profiles of the endpoint device and support various authentication methods5. Neither of these modules directly protect the user from a phishing attack.
References :=
* Roaming Client: Umbrella Roaming Security (Integration with AnyConnect)
* Secure Umbrella Roaming: Cisco Secure Client (Formerly AnyConnect)
* Cisco Identity Services Engine
* [Cisco AnyConnect Secure Mobility Client Administrator Guide, Release 4.9 - Posture Module]
* [Cisco AnyConnect Secure Mobility Client Administrator Guide, Release 4.9 - Network Access Manager Module]

Simple Custom Detection is a feature of Cisco AMP for Endpoints that allows administrators to block specific files based on their SHA-256 or MD5 hashes. This feature can be used to detect and quarantine files of unknown disposition, such as abc424400664.zip, by adding their hashes to a custom list in the AMP portal.
The list can then be applied to a policy that is assigned to the endpoints. Simple Custom Detection works on files of any type, size, or platform, unlike the other options that are either platform-specific (Android Custom Detection), size-limited (Blocked Application), or signature-based (Advanced Custom Detection). References: 1, 2, 3