USB ports are a common attack vector that can be used to deliver malware, steal data, or compromise systems. The first step to mitigate this vulnerability is to check the configurations of the company assets and disable or restrict the USB ports if possible. This will prevent unauthorized devices from being connected and reduce the attack surface. The other options are also important, but they are not the first priority in this scenario.
References:
* CompTIA CySA+ CS0-003 Certification Study Guide, page 247
* What are Attack Vectors: Definition & Vulnerabilities, section "How to secure attack vectors"
* Are there any attack vectors for a printer connected through USB in a Windows environment?, answer by user "schroeder"

A cloud access security broker (CASB) is a tool that can help reduce the risk of shadow IT in the enterprise by providing visibility and control over cloud applications and services. A CASB can enable policy enforcement by blocking unauthorized or risky cloud applications, enforcing data loss prevention rules, encrypting sensitive data, and detecting anomalous user behavior.

Based on the events in the log, the most likely occurrence is that an adversary is performing a vulnerability scan. The log shows LDAP read operations and EDR enumerating local groups, which are indicative of an adversary scanning the system to find vulnerabilities or sensitive information. The final entry shows SMB connection attempts to multiple hosts from a single host, which could be a sign of network discovery or lateral movement. References: CompTIA CySA+ Study Guide: Exam CS0-003, 3rd Edition, Chapter 4: Security Operations and Monitoring, page 161; Monitor logs from vulnerability scanners, Section: Reports on Nessus vulnerability data.

A social engineering attack is underway is the most likely explanation for the outbound traffic to a host IP that resolves to https://offce365password.acme.co, while the site's standard VPN logon page is www.acme.com
/logon. A social engineering attack is a technique that exploits human psychology and behavior to manipulate people into performing actions or divulging information that benefit the attackers. A common type of social engineering attack is phishing, which involves sending fraudulent emails or other messages that appear to come from a legitimate source, such as a company or a colleague, and lure the recipients into clicking on malicious links or attachments, or entering their credentials or other sensitive information on fake websites. In this case, the attackers may have registered a domain name that looks similar to the company's domain name, but with a typo (offce365 instead of office365), and set up a fake website that mimics the company's VPN logon page. The attackers may have also sent phishing emails to the company's employees, asking them to reset their passwords or log in to their VPN accounts using the malicious link. The security analyst should investigate the source and content of the phishing emails, and alert the employees not to click on any suspicious links or enter their credentials on any untrusted websites. Official References:
* https://partners.comptia.org/docs/default-source/resources/comptia-cysa-cs0-002-exam-objectives
* https://www.comptia.org/certifications/cybersecurity-analyst
* https://www.comptia.org/blog/the-new-comptia-cybersecurity-analyst-your-questions-answered