Explanation
Waste that is transported or diverted to landfills can have negative impacts on the environment, such as occupying valuable land, contaminating soil and water, and emitting harmful gases. One of the most significant impacts is the production of methane, a potent greenhouse gas that contributes to global warming and climate change. Methane is generated when organic waste decomposes anaerobically (without oxygen) in landfills. Methane has a global warming potential 28 times higher than carbon dioxide over a 100-year period12. References: LEED v4 Green Associate Candidate Handbook1, EPA's Landfill Methane Outreach Program2

According to the U.S. Energy Information Administration, space heating accounted for about 32% of energy use for all U.S. commercial buildings in 2018, followed by ventilation and lighting, each at about 10%1. Space heating is the largest single energy end use in U.S. office buildings as well2.
Reference:
Use of energy in commercial buildings - U.S. Energy Information Administration (EIA)1 DataTrends: Energy Use in Office Buildings | ENERGY STAR2

According to LEED, one of the factors that should be considered when locating a site for a project is the infrastructure context. The infrastructure context refers to the existing physical systems that support a site, such as roads, utilities, transit networks, water supply, wastewater treatment, stormwater management, and waste disposal. Choosing a site that has access to adequate infrastructure can reduce the environmental impacts of developing new infrastructure, such as land disturbance, resource consumption, energy use, emissions, and pollution. The LEED Green Associate Candidate Handbook states that one of the intents of the Location and Transportation category is to "reduce environmental harm from transportation infrastructure" [1, p. 12]. Reference: LEED Green Associate Candidate Handbook, [Location and Transportation | U.S. Green Building Council]

Explanation
The Integrative Process Credit in LEED v4 requires the project team to implement an integrative process that enables them to discover unique opportunities for enhancing project performance and environmental benefits1. The project team should identify and use opportunities to achieve synergies across disciplines and building systems2.
References := Integrative process | U.S. Green Building Council, LEED Integrative Process Credit Explained - Projectific, Inc.