Install Veeam Agent and Veeam Backup and Replication. Backup for 365 can be only configured, but not deployed.
https://helpcenter.veeam.com/docs/vac/provider_admin/capability.html?ver=80

To dynamically include VMware VMs with a custom application installed in a backup job, the most efficient approach is C: Create a backup job based on vSphere tags. VMware vSphere tagging allows administrators to assign metadata to VMs, making it easier to categorize and manage them according to various criteria, such as application type, department, or any custom criteria relevant to the organization. Veeam Backup & Replication can leverage these tags to dynamically include VMs in backup jobs. By setting up a backup job to include VMs tagged with a specific identifier related to the custom application, any VM tagged accordingly will be automatically included in the backup job. This approach simplifies management, ensures consistency, and allows for the flexible and dynamic grouping of VMs based on changing criteria without the need for manual adjustments to the backup job configuration.

Reference: https://helpcenter.veeam.com/docs/backup/vsphere/vcloud_regular_vm_restore.html?ver=100

Veeam Enterprise Manager provides centralized management for Veeam Backup & Replication environments. It enables the administrator to manage licensing and role-based access control across multiple Veeam Backup servers in different locations, offering a unified control panel with minimal effort compared to other options that would require more complex setups or custom development work.