HPE SimpliVity is a hyperconverged infrastructure solution that combines compute, storage, networking, and data services in a single platform. HPE SimpliVity integrates with HPE StoreOnce, a disk-based backup appliance, to provide efficient and reliable data protection and disaster recovery for distributed edge sites12.
HPE SimpliVity uses HPE StoreOnce Catalyst, a deduplication protocol, to replicate data from HPE SimpliVity clusters to HPE StoreOnce appliances. HPE SimpliVity leverages its global deduplication and compression capabilities to send only the unique data blocks to HPE StoreOnce, reducing the bandwidth and storage requirements34.
To optimize the replication performance, the design aspects that need to be evaluated are the number of the HPE SimpliVity clusters and Catalyst stores used. According to the HPE SimpliVity with HPE StoreOnce Reference Architecture document, the following best practices are recommended:
Use one Catalyst store per HPE SimpliVity cluster. This simplifies the configuration and management, and avoids potential performance issues due to contention or fragmentation.
Use one Catalyst store per HPE StoreOnce appliance. This ensures optimal deduplication ratios and avoids unnecessary data movement across appliances.
Use one HPE StoreOnce appliance per HPE SimpliVity federation. This minimizes the network hops and latency, and maximizes the throughput and efficiency.
Use dedicated network interfaces and VLANs for the replication traffic. This isolates the replication traffic from the production traffic, and provides better security and performance.
The other options are not relevant for optimizing the replication performance. The performance optimization features provided by VMFS datastores compared to NFS datastores are not applicable for HPE SimpliVity, as it uses its own file system and data virtualization platform. The intelligent workload optimizer settings are not related to the replication performance, but to the VM placement and load balancing within the HPE SimpliVity cluster. The HPE SimpliVity model used does not affect the replication performance, as long as it meets the minimum requirements for the HPE StoreOnce integration.
References:
1: SimpliVity Hyperconverged | HPE 2: Expand backups to secondary storage with HPE SimpliVity hyperconverged infrastructure and HPE StoreOnce 3: HPE SimpliVity with HPE StoreOnce 4: HPE SimpliVity with HPE StoreOnce: A better together story : [HPE SimpliVitywith HPE StoreOnce Reference Architecture] : [HPE SimpliVity Data Virtualization Platform] : [HPE SimpliVity Intelligent Workload Optimizer]

HPE SimpliVity provides storage HA by creating two copies of each virtual machine data across different nodes in a cluster. This ensures that the virtual machines can continue to run even if one node fails. However, this also consumes twice the storage capacity for each virtual machine. For development virtual machines that do not require storage HA, the customer can save storage capacity by creating a single-replica datastore for these virtual machines. A single-replica datastore is a datastore that has only one copy of the virtual machine data on one node. This reduces the storage consumption by 50%, but also increases the risk of data loss and unavailability in case of node failure. Therefore, the customer should carefully weigh the trade-offs between storage efficiency and data protection when using a single-replica datastore. References: HPE SimpliVity Data Virtualization Platform; HPE SimpliVity User Guide

HPE SimpliVity RapidDR is a disaster recovery orchestration tool that automates and simplifies the recovery process of VMs protected by HPE SimpliVity backups. It can be used in the event of disaster to efficiently restore VMs across the primary and secondary sites, which consist of multiple HPE SimpliVity nodes12.
HPE SimpliVity RapidDR requires VMware vCenter Server, a centralized management platform for VMware vSphere environments, to perform the recovery operations. VMware vCenter Server is licensed per instance, which means that each vCenter Server installation requires a separate license3 .
To reduce the vCenter Server license cost, a customer can use only a single vCenter Server instance to manage the HPE SimpliVity federation, which is a group of HPE SimpliVity clusters that share the same configuration and policies. This deployment scenario is possible when the federation is managed centrally, which means that all the HPE SimpliVity nodes are registered to the same vCenter Server instance, regardless of their physical location .
The other options are not valid for reducing the vCenter Server license cost. The number of VMs covered by a single recovery plan does not affect the vCenter Server license requirement, as long as the VMs are managed by the same vCenter Server instance. Enabling Enhanced Linked Mode for vCenter allows multiple vCenter Server instances to share information and provide a single pane of glass view, but it does not eliminate the need for separate licenses for each vCenter Server instance. Disabling Intelligent Workload Optimizer, a feature that balances the VM workload across the HPE SimpliVity cluster, has no impact on the vCenter Server license requirement.
References:
1: HPE SimpliVity RapidDR 2: HPE SimpliVity RapidDR - Starter License - 25 VMs - CDW 3: VMware vCenter Server - VMware : VMware vCenter Server Licensing, Pricing and Packaging : [HPE SimpliVity Federation Design and Scaling Guide] : [HPE SimpliVity with HPE StoreOnce Reference Architecture] :
[HPE SimpliVity Data Virtualization Platform] : [HPE SimpliVity Intelligent Workload Optimizer] : [HPE SimpliVity Stretched Cluster Guide] : [HPE SimpliVity Remote RapidDR Software Installation and Startup Service]